In Africa, a key challenge in health emergencies is ensuring a reliable blood supply. This is vital for addressing various health issues. The session, “Enhancing Africa’s health security: Blood as a cornerstone for pandemic preparedness,” highlights the importance of a robust blood supply system. It focuses on private sector involvement, addressing challenges, exploring opportunities, and developing strategies for strengthening blood availability. This aligns with the New Public Health Order’s emphasis on collaborative partnerships for public health in Africa. The session aims to provide insights, foster collaboration, and generate practical solutions for a resilient blood supply system.